IMAGING BEYOND BARRIERS!

Using Abberior STED-FCS, a team from four European countries, comprising Christian Eggeling (Leibniz IPHT & Friedrich Schiller University Jena) and Delphine Muriaux (Montpellier Infectious Disease Research Institute) discovered the existence and composition of a lipid-based platform for HIV virus assembly.
These results provide novel molecular insights on HIV virus assembly and are a starting point for the development of new antiviral drugs.

Citation: C. Favard, J. Chojnack, P. Merida, N. Yandrapalli, J. Mak, C. Eggeling and D. Muriaux, "HIV-1 Gag specifically restricts PI(4,5)P2 and cholesterol mobility in living cells creating a nanodomain platform for virus assembly", Science Advances, 02 Oct 2019: Vol. 5, no. 10.

Please check out the new publication:

K. C. Gwosch,  J. K. Pape,  F. Balzarotti, P. Hoess,  J. Ellenberg, J. Ries, S. W. Hell, "MINFLUX nanoscopy delivers multicolor nanometer 3D-resolution in (living) cells", bioRxiv (2019)

Boost your stability:

Our new push-button STEADYFOCUS module ensures that your images are perfectly in focus over days.

J.-G. Schloetel, J. Heine, A. F. Cowman, M. Pasternak, "Guided STED nanoscopy enables super-resolution imaging of blood stage malaria parasites", Nature Scientific Reports, Volume 9, Article number: 4674 (2019)

The recent and most fruitful collaboration between Abberior Instruments and SVI has brought about cutting-edge superresolution at maximum convenience and benefit for our STEDYCON users.

As exemplified in the panels below, the combination of top-notch STED imaging with a sophisticated deconvolution method reveals the faintest details in the sample. Moreover, all this unfolds at the push of a button!

For any questions & quotations: sales@abberior-instruments.com

Please check out the new Publication (link below): 

A combination of expansion microscopy and DyMIN 3D STED reveals the ultrastructure of centrioles. Chlamydomonas reinhardtii centrioles immunostained with Abberior STAR RED for polyglutamylated tubulin. Samples by P. Guichard & D. Gambarotto (University of Geneva).

D. Gambarotto, F. U. Zwettler, M. Le Guennec, M. Schmidt-Cernohorska, D. Fortun, S. Borgers, J. Heine, J. G. Schloetel, M. Reuss, M. Unser, E. S. Boyden, M. Sauer, V. Hamel & P. Guichard, “Imaging cellular ultrastructures using expansion microscopy (U-ExM)”, Nature Methods (2019)

M. Bernhardt, J.-D. Nicolas, M. Osterhoff, H. Mittelstädt, M. Reuss, B. Harke, A. Wittmeier, M. Sprung, S. Köster, T. Salditt, "Correlative microscopy approach for biology using X-ray holography, X-ray scanning diffraction and STED microscopy", Nature Communications, Volume 9, Article number: 3641 (2018)

J. Heine, C. A. Wurm, J. Keller-Findeisen, A. Schönle, B. Harke, M. Reuss, F. R. Winter, G. Donnert, "Three dimensional live-cell STED microscopy at increased depth using a water immersion objective", Review of Scientific Instruments (2018)

DyMIN STED is a co-development between Stefan Hell and coworkers and Abberior Instruments. Read all technical details in the current PNAS publication, 2017: 

J. Heine, M. Reuss, B. Harke, E. D'Este, S. J. Sahl and S. W. Hell, "Adaptive-illumination STED nanoscopy", PNAS (2017)

Nature review on DyMIN STED: G. Pacchioni, "Always look on the bright side of the fluorophore", Nature Review Materials (2017)