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Abberior Instruments GmbH
Abberior Instruments GmbH

IMAGING BEYOND BARRIERS!

MINFLUX: The first commercial microscope with molecule-size resolution

 

MINFLUX (minimal photon flux) is the cutting-edge method for localizing fluorescent molecules  with unprecedented precision. 

By introducing the MINFLUX nanoscope, Abberior Instruments offers the first commercially available light microscope with a resolution of the size of a molecule. 

Click here to learn more...

NEW: Adaptive Optics with a deformable mirror

Learn how to stay sharp, even when focusing deep into tissue here.

New Insights on HIV virus revealed by Abberior STED-FCS

Using Abberior STED-FCS, a team from four European countries, comprising Christian Eggeling (Leibniz IPHT & Friedrich Schiller University Jena) and Delphine Muriaux (Montpellier Infectious Disease Research Institute) discovered the existence and composition of a lipid-based platform for HIV virus assembly.
These results provide novel molecular insights on HIV virus assembly and are a starting point for the development of new antiviral drugs.

Citation: C. Favard, J. Chojnack, P. Merida, N. Yandrapalli, J. Mak, C. Eggeling and D. Muriaux, "HIV-1 Gag specifically restricts PI(4,5)P2 and cholesterol mobility in living cells creating a nanodomain platform for virus assembly"Science Advances02 Oct 2019: Vol. 5, no. 10.

MINFLUX goes 3D

Below 3 x 3 x 3 nm resolution in all directions

Top row: MINFLUX image of individual nuclear pore complexes (observe the familiar eight-fold symmetry) with < 3 nm localization precision. Bottom: MINFLUX image of nuclear pore complexes in a large field of view.

Please check out the new publication:

K. C. Gwosch,  J. K. Pape,  F. Balzarotti, P. Hoess,  J. Ellenberg, J. Ries, S. W. Hell, "MINFLUX nanoscopy delivers multicolor nanometer 3D-resolution in (living) cells", bioRxiv (2019)

Abberior Instruments STEADYFOCUS

Boost your stability:

Our new push-button STEADYFOCUS module ensures that your images are perfectly in focus over days.

Abberior Instruments Facility Line

DyMIN STED + easy3D STED = unprecedented 3D STED resolution

Please check out the new Publication (link below): 

A combination of expansion microscopy and DyMIN 3D STED reveals the ultrastructure of centrioles. Chlamydomonas reinhardtii centrioles immunostained with Abberior STAR RED for polyglutamylated tubulin. Samples by P. Guichard & D. Gambarotto (University of Geneva).

D. Gambarotto, F. U. Zwettler, M. Le Guennec, M. Schmidt-Cernohorska, D. Fortun, S. Borgers, J. Heine, J. G. Schloetel, M. Reuss, M. Unser, E. S. Boyden, M. Sauer, V. Hamel & P. Guichard, “Imaging cellular ultrastructures using expansion microscopy (U-ExM)”, Nature Methods (2019)

Explanation videos of Adaptive Illumination (DyMIN, RESCue and MINFIELD STED)


 

 

DyMIN STED is a co-development between Stefan Hell and coworkers and Abberior Instruments. Read all technical details in the current PNAS publication, 2017: 

J. Heine, M. Reuss, B. Harke, E. D'Este, S. J. Sahl and S. W. Hell, "Adaptive-illumination STED nanoscopy", PNAS (2017)

Nature review on DyMIN STED: G. Pacchioni, "Always look on the bright side of the fluorophore", Nature Review Materials (2017)

From zero to STED in no time

Follow along with the incredibly quick installation of a STEDYCON super resolution microscope, uncut. We go from opening the carton to the first super-resolution STED image in under three minutes. Don't forget to check out the real time movie here: https://youtu.be/wnFnyt8yJyA