The only superresolution microscope with true resolution below 20 nm* - MINFIELD confines the field of view to the inner minimum of the STED-doughnut (i.e. imaging fields of e.g. 100 x 100 nm). The excess doughnut intensity, connected to photobleaching, are sidestepped to the scan field. The dramatically higher signal allows increased resolutions below 20 nm at superior fluorescence contrast.
*depending on the fluorescent marker used
MINFIELD STED is a co-development between Stefan Hell and coworkers and Abberior Instruments. Read all technical details in the current PNAS publication, 2017: